Journal: Scientific Reports
Article Title: Developmental overproduction of cortical superficial neurons impairs adult auditory cortical processing
doi: 10.1038/s41598-025-95968-x
Figure Lengend Snippet: XAV939 treated mice exhibit auditory response deficits. ( a ) Schematics of head-fixed behavioral training. Elements located inside a soundproof box are positioned within the dashed box. Image was created in BioRender. Merkler, M. (2025) https://BioRender.com/a37u531 . ( b ) Timeline of events in the auditory detection task. Trial starts with the sound onset. If the mouse licks during the response window (lasting 1 s), the sound turns off and water reward is delivered. ( c ) Diagram of possible events and outcomes during an auditory detection task session. ( d ) Comparison of training time the mice needed to pass each of the 3 phases in the behavioral assessment. ( e ) Comparison of d’ between control and treated mice across sound intensities ( n = 11 vs. 16 mice; 1 session per mouse). ( f ) Comparison of reaction time between control and treated mice across sound intensities ( n = 11 vs. 16 mice; 1 session per mouse). Error bars indicate SEM; * p < 0.05, ** p < 0.01; t -test ( d ), two-way ANOVA ( e and f ).
Article Snippet: Head-fixed, awake mice were sat in a restraining tube within a soundproof box (Industrial Acoustics Company).
Techniques: Comparison, Control